This article explores the possibility that the inversion of Platonism, a task associated with Nietzsche in Michel Foucault’s The Anthropological Question, constitutes a basis from which it is possible to understand much of the organization of the aforementioned course by this French author. In order to corroborate this hypothesis, this paper reviews not only texts by Plato and Nietzsche, as well as Foucault’s aforementioned course, but also later contributions by the latter thinker, with special attention to the first lessons of his Hermeneutics of the Subject, from 1982.